3-(2-IODO-6-METHOXYPHENOXY)PROPAN-1-OL synthesis

1synthesis methods

Product Name:3-(2-IODO-6-METHOXYPHENOXY)PROPAN-1-OL
CAS Number:1241505-33-8
Molecular formula:C10H13IO3
Molecular Weight:308.11

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Yield:1241505-33-8 60%

Reaction Conditions:

with caesium carbonate in N,N-dimethyl-formamide at 20;

Steps:

3.4

A mixture of compound 4 (40 g, 0.16 mol), Br(CH₂)₃OH (33.3 g, 0.24 mol) and Cs₂CO₃ (104.3 g, 0.32 mol) in DMF (200 mL) was stirred at room temperature overnight, then diluted with water. The resulting mixture was extracted with EA. The combined extracts were washed with brine, dried over Na₂SO₄ and then purified on silica gel (PE: EA = 30: 1) to give 48 g of compound 5 in 60 % yields.

References:

WO2010/94242,2010,A1 Location in patent:Example 3.4