3-(2-methoxyethoxy)prop-1-ene synthesis

Yield:10021-77-9 100%

Reaction Conditions:

with thionyl chloride;N,N-dimethyl-formamide in dichloromethane at 20; for 0.5 h;

Steps:

98.A Step A: 2,2'-thiodiacetyl chloride_

77mg (0.42mmol, 1.0eq) 2,2-dithiodiacetic acid was dissolved in 10mL dichloromethane, and 150mg (1.27mmol, 3.0eq) thionyl chloride was added at room temperature, and then 1 drop of N, N-dimethylformamide was added. Stir at room temperature for 30 minutes. TLC monitored the completion of the reaction, and the reaction system was concentrated to dryness which was directly used in the next step reaction (93mg, yield=100%).

References:

EP3950677,2022,A1 Location in patent:Paragraph 0529-0530