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3-(2-OXOPROPYL)-4(3H)-QUINAZOLINONE synthesis

5synthesis methods
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Yield:5632-37-1 88%

Reaction Conditions:

Stage #1: 4-quinazolinolwith potassium carbonate in N,N-dimethyl-formamide at 20; for 0.5 h;
Stage #2: 1-bromoacetone in N,N-dimethyl-formamide at 20; for 24 h;

References:

Chang, Ken-Ming;Chen, Li-Chai;Tzeng, Cherng-Chyi;Lu, Yao-Hua;Chen, I-Li;Juang, Shin-Hun;Wang, Tai-Chi [Journal of the Chinese Chemical Society,2018,vol. 65,# 9,p. 1110 - 1118]