ChemicalBook CAS DataBase List 3-(2H-Pyrazol-3-yl)benzonitrile

3-(2H-Pyrazol-3-yl)benzonitrile synthesis

2synthesis methods

Product Name:3-(2H-Pyrazol-3-yl)benzonitrile
CAS Number:149739-51-5
Molecular formula:C10H7N3
Molecular Weight:169.18

3-[(E)-3-(DIMETHYLAMINO)-2-PROPENOYL]BENZENECARBONITRILE

179055-13-1
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149739-51-5
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Yield:149739-51-5 1.4 g

Reaction Conditions:

with hydrazine hydrate in ethanol at 90; for 3 h;

Steps:

Step 2: Preparation of 3-(1 H-pyrazol-3-yl)benzonitrile

A mixture of (E)-3-(3-(Dimethylamino)acryloyl)benzonitrile (2.00 g, 10 mmol) and hydrazine monohydrate (1 .50 g, 30 mmol) in ethanol (20 ml_) was stirred at 80°C for 3 hours. The product was indicated present via UPLC analysis. The mixture concentrated under reduced pressure, and the residue was purified by flash column chromatography through silica gel using a gradient of 0-30% ethyl acetate in petroleum ether. Product 3-(1 H-pyrazol-3-yl)benzonitrile (1.40 g, 8.3 mmol, 83 %) was afforded as a light yellow solid. NMR data unavailable; LCMS (ESI) m/z: 170 [M+H]+.

References:

WO2021/247841,2021,A1 Location in patent:Page/Page column 57-57

6136-68-1
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149739-51-5
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References