3(2H)-Pyridazinone, 6-(phenylmethoxy)- synthesis

Yield:3605-12-7 89%

Reaction Conditions:

with sodium acetate;acetic acid at 120; for 8 h;

Steps:

VI.1.b

Vl.^j .b 6-Benzyloxy-2H-pyridazin-3-one; 15.5 g (70.0 mmol) 3-Benzyloxy-6-chloro-pyridazine are dissolved in 100 ml acetic acid and 6.3 g (77.0 mmol) sodium acetate are added. The mixture is stirred for 8 hours at 120°C. After that time the solvent is evaporated. The residue is taken up in methylene chloride and washed four times with 0.1 N acetic acid. The organic phase is separated and the solvent is evaporated.Yield: 40.21 g (89% of theory),R_f value: 0.50 (silica gel, methylene chloride/methanol = 9:1 ) M. p. 170-173°C CnH₉CIN₂O

References:

WO2007/48802,2007,A1 Location in patent:Page/Page column 79-80