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3-(3,4-dichlorophenyl)-2-Propynoic acid synthesis

2synthesis methods
-

Yield: 41%

Reaction Conditions:

Stage #1:3,4-dichlorophenylacetylene with n-butyllithium in tetrahydrofuran;hexane at 20; for 1 h;
Stage #2:carbon dioxide in tetrahydrofuran;hexane at 20; for 1 h;

References:

Onda, Kenichi;Shiraki, Ryota;Yonetoku, Yasuhiro;Momose, Kazuhiro;Katayama, Naoko;Orita, Masaya;Yamaguchi, Tomohiko;Ohta, Mitsuaki;Tsukamoto, Shin-ichi [Bioorganic and Medicinal Chemistry,2008,vol. 16,# 18,p. 8627 - 8634] Location in patent:experimental part