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3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]aniline synthesis

4synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: α-picoline / 0 - 20 °C
2: toluene / 3 h / Reflux
3: zinc; ammonium chloride / methanol; tetrahydrofuran; water / 4 h / Reflux

References:

He, Hai-Bing;Gao, Li-Xin;Zhou, Yue-Yang;Liu, Ting;Tang, Jie;Gong, Xue-Ping;Qiu, Wen-Wei;Li, Jing-Ya;Li, Jia;Yang, Fan [Heterocycles,2012,vol. 85,# 11,p. 2693 - 2712]