3-(3,5-DIFLUOROPHENYL)PROPENOL synthesis
- Product Name:3-(3,5-DIFLUOROPHENYL)PROPENOL
- CAS Number:405937-98-6
- Molecular formula:C9H8F2O
- Molecular Weight:170.16
84315-23-1
122 suppliers
$19.00/5g
405937-98-6
21 suppliers
$45.00/10mg
Yield:405937-98-6 95%
Reaction Conditions:
Stage #1: (trans)-3-(3,5-difluorophenyl)acrylic acidwith diisobutylaluminium hydride in dichloromethane at -78 - -30;Inert atmosphere;
Stage #2: with methanol in dichloromethane;Inert atmosphere;
References:
Vu, An T.;Cohn, Stephen T.;Zhang, Puwen;Kim, Callain Y.;Mahaney, Paige E.;Bray, Jenifer A.;Johnston, Grace H.;Koury, Elizabeth J.;Cosmi, Scott A.;Deecher, Darlene C.;Smith, Valerie A.;Harrison, James E.;Leventhal, Liza;Whiteside, Garth T.;Kennedy, Jeffrey D.;Trybulski, Eugene J. [Journal of Medicinal Chemistry,2010,vol. 53,# 5,p. 2051 - 2062] Location in patent:experimental part
84315-23-1
122 suppliers
$19.00/5g
543-27-1
246 suppliers
$10.00/5g
405937-98-6
21 suppliers
$45.00/10mg
721443-73-8
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405937-98-6
21 suppliers
$45.00/10mg