3,3′-Bithiophene-5-carboxaldehyde synthesis
- Product Name:3,3′-Bithiophene-5-carboxaldehyde
- CAS Number:137320-59-3
- Molecular formula:C9H6OS2
- Molecular Weight:194.27
872-31-1
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$9.00/1g
18791-75-8
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$9.00/5g
137320-59-3
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$97.09/1g
Yield:137320-59-3 65%
Reaction Conditions:
Stage #1: 3-Bromothiophenewith n-butyllithium in diethyl ether at -78; for 0.5 h;Metallation;
Stage #2: with tributyltin chloride in diethyl ether at -70 - 20; for 2 h;Condensation;
Stage #3: 4-Bromothiophen-2-aldehydewith tetrakis(triphenylphosphine) palladium(0) in xylene at 140; for 2 h;Substitution;
References:
Gotteland;Junquero;Oms;Delhon;Halazy [Medicinal Chemistry Research,1996,vol. 6,# 5,p. 333 - 342]