3-(3-CHLOROPHENYL)-4'-METHOXYPROPIOPHENONE synthesis

5synthesis methods

Product Name:3-(3-CHLOROPHENYL)-4'-METHOXYPROPIOPHENONE
CAS Number:898762-26-0
Molecular formula:C16H15ClO2
Molecular Weight:274.74

2-Propen-1-one, 3-(3-chlorophenyl)-1-(4-methoxyphenyl)-

52182-25-9
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3-(3-CHLOROPHENYL)-4'-METHOXYPROPIOPHENONE

898762-26-0
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$433.00/1g

Yield:898762-26-0 94%

Reaction Conditions:

with methanol;C₂₅H₂₉ClNO₂Rh;potassium carbonate at 90; for 1 h;chemoselective reaction;

Steps:

2.2. Transfer hydrogenation of unsaturated ketones in methanol

A Radley tube was charged with an unsaturated ketone (0.3mmol), catalyst (0.003 mmol) and K2CO3 (0.25 eq), to which was introduced MeOH (1.5 mL). The reaction mixture was heated to reflux at 90 °C for 1 h. The resulting mixture was then cooled to room temperature, followed by solvent evaporation under vacuum. The product was purified by flash column chromatography (hexane/ethyl acetate, 4:1).

References:

Aboo, Ahmed H.;Begum, Robina;Zhao, Liangliang;Farooqi, Zahoor H.;Xiao, Jianliang [Cuihua Xuebao/Chinese Journal of Catalysis,2019,vol. 40,# 11,p. 1795 - 1799]

873-63-2 Synthesis