3-(3-CHLOROPHENYL)PROPIOPHENONE synthesis

9synthesis methods

Product Name:3-(3-CHLOROPHENYL)PROPIOPHENONE
CAS Number:58122-03-5
Molecular formula:C15H13ClO
Molecular Weight:244.72

100-52-7 Synthesis

100-52-7
941 suppliers
$20.37/250g

587-04-2 Synthesis

587-04-2
412 suppliers
$7.00/25g

58122-03-5
12 suppliers
$433.00/1g

Yield:58122-03-5 58%

Reaction Conditions:

with Eosin Y in fluorobenzene at 80;Irradiation;regioselective reaction;

Steps:

Ethyl 4-(3-Phenylpropanoyl)benzoate (8)

General procedure: A 10 mL reaction tube equipped with a magnetic stirrer bar wascharged with ethyl 4-formylbenzoate (1.0 mmol, 5.0 equiv),styrene (0.2 mmol, 1.0 equiv), eosin Y (0.01 mmol, 0.05 equiv),and PhF (4 mL). The tube was then sealed and degassed by usingan argon balloon with a subsequent backfill with argon. Thetube was then equipped with an argon balloon and placedunder blue LEDs (3 m strip; 27 W) and irradiated for 72 h at80 °C. The solvent was removed on a rotary evaporator underreduced pressure, and the residue was purified by column chromatography[silica gel, hexane-EtOAc (15:1 to 1:1)] to give acolorless liquid

References:

Liu, Haiwang;Xue, Fei;Wang, Mu;Tang, Xinxin;Wu, Jie [Synlett,2021,vol. 32,# 4,p. 406 - 410] Location in patent:supporting information