3,3-Difluoro-5-methyl-1,3-dihydro-indol-2-one synthesis
- Product Name:3,3-Difluoro-5-methyl-1,3-dihydro-indol-2-one
- CAS Number:221665-90-3
- Molecular formula:C9H7F2NO
- Molecular Weight:183.15
608-05-9
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221665-90-3
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Yield:221665-90-3 88%
Reaction Conditions:
with diethylamino-sulfur trifluoride in dichloromethane at 20; for 4 h;Inert atmosphere;
Steps:
3.1.5. General Procedure for the Preparation of 3,3-difluoroindolin-2-one (13a-e)
General procedure: Briefly, 3.4 mmol (1 eq) of the corresponding isatins 11a-e, 17 mmol (5 eq) of DAST and30 mL of CH2Cl2 were added into a monotube flask. The mixture was maintained at roomtemperature with magnetic stirring under a nitrogen atmosphere for 4 h. The progress ofthe reaction was monitored using TLC (hexane/ethyl acetate 7:3). The mixture was washedwith water (3 40 mL), then the organic phase was dried with anhydrous Na2SO4, and thesolvent was removed by evaporation. The product was obtained as a white solid.The analyses can be summarized as follows:
References:
Bastos, Monica;Boechat, Nubia;Dantas, Rafael;Moura, Stefany;Neto, Jo?o;Oliveira, Andressa;Pimentel, Luiz;Silva, Floriano [Molecules,2022,vol. 27,# 3,art. no. 750]
40664-49-1
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221665-90-3
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