3,3-Difluorocyclobutanemethanamine synthesis

Yield:-

Reaction Conditions:

with palladium 10% on activated carbon;hydrogen in methanol at 25;

References:

MacSari, Istvan;Besidski, Yevgeni;Csjernyik, Gabor;Nilsson, Linda I.;Sandberg, Lars;Yngve, Ulrika;Ahlin, Kristofer;Bueters, Tjerk;Eriksson, Anders B.;Lund, Per-Eric;Venyike, Elisabet;Oerther, Sandra;Hygge Blakeman, Karin;Luo, Lei;Arvidsson, Per I. [Journal of Medicinal Chemistry,2012,vol. 55,# 15,p. 6866 - 6880] Location in patent:supporting information; experimental part