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3,3-difluorocyclohexane-1-carbonitrile synthesis

1synthesis methods
3,3-difluorocyclohexane-1-carbonitrile

1227808-14-1
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Yield:1227808-14-1 50%

Reaction Conditions:

with (bis-(2-methoxyethyl)amino)sulfur trufluoride in dichloromethane at 20;

References:

Chen, Xiangyang;Pierce, Betsy;Naing, Win;Grapperhaus, Margaret L.;Phillion, Dennis P. [Bioorganic and Medicinal Chemistry Letters,2010,vol. 20,# 10,p. 3107 - 3111] Location in patent:scheme or table