3,3-DIFLUOROPENTANEDIOIC ACID synthesis
- Product Name:3,3-DIFLUOROPENTANEDIOIC ACID
- CAS Number:41131-19-5
- Molecular formula:C5H6F2O4
- Molecular Weight:168.1
2710-66-9
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41131-19-5
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Yield:41131-19-5 67%
Reaction Conditions:
with hydrogenchloride;formic acid in water at 100; for 48 h;
Steps:
Hydrolysis Protocol A2
General procedure: A mixture of the ester 2 (1 equiv), formic acid (4 equiv), and 20% hydrochloric acid (3 equiv of HCl) was stirred at 100°C with 10cm Vigreux column for 2 days. The reaction mixture was saturated with NaCl, and the product was extracted with dichloromethane (for the substance 2p, the precipitated product was filtered off and washed with cold water). The extracts were dried, evaporated, and distilled. The bp and yields of products 10 are given in Table 1.
References:
Bugera, Maksym Y.;Khairulin, Andrii R.;Kliukovskyi, Denys V.;Ryabukhin, Sergey V.;Semenov, Sergey V.;Shevchenko, Valerii O.;Tarasenko, Karen V.;Trofymchuk, Serhii A.;Volochnyuk, Dmitriy M. [Synlett,2020,vol. 31,# 6,p. 565 - 574]
105-50-0
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41131-19-5
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