![](/CAS/GIF/68332-33-2.gif)
3-(3-IODO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER synthesis
- Product Name:3-(3-IODO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
- CAS Number:68332-33-2
- Molecular formula:C11H11IO3
- Molecular Weight:318.11
![ETHYL 3-IODOBENZOATE](/CAS/GIF/58313-23-8.gif)
58313-23-8
138 suppliers
$7.00/5g
![Ethyl acetate](/CAS/GIF/141-78-6.gif)
141-78-6
605 suppliers
$24.69/250ml
![3-(3-IODO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER](/CAS/GIF/68332-33-2.gif)
68332-33-2
22 suppliers
$59.39/1g
Yield:68332-33-2 100%
Reaction Conditions:
with potassium tert-butylate in tetrahydrofuran at 0 - 20; for 2.25 h;
Steps:
23.23A
Ethyl-3-iodobenzoate (25.4 g, 92.0 mmol) was dissolved in THF (60 mL) and cooled to 0° C. followed by the addition of KOt-Bu (20.6 g, 184 mmol). The mixture was stirred for 15 minutes followed by the addition of ethyl acetate (8.91 g, 101 mmol). The mixture was warmed to ambient temperature, stirred for 2 hours, diluted with aqueous HCl (10%, 200 mL) and extracted with ethyl acetate (2 150 mL). The combined organic layers were dried (Na 2SO 4), filtered and concentrated in vacuo to provide the titled compound (29.3 g, 100%).
References:
US2004/214870,2004,A1 Location in patent:Page 27
![3'-IODOACETOPHENONE](/CAS/GIF/14452-30-3.gif)
14452-30-3
131 suppliers
$8.00/1g
![Diethyl carbonate](/CAS/GIF/105-58-8.gif)
105-58-8
450 suppliers
$17.00/25g
![3-(3-IODO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER](/CAS/GIF/68332-33-2.gif)
68332-33-2
22 suppliers
$59.39/1g
![ETHYL 3-IODOBENZOATE](/CAS/GIF/58313-23-8.gif)
58313-23-8
138 suppliers
$7.00/5g
![3-(3-IODO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER](/CAS/GIF/68332-33-2.gif)
68332-33-2
22 suppliers
$59.39/1g