3-(3-IODOPHENYL)-BETA-ALANINE synthesis
- Product Name:3-(3-IODOPHENYL)-BETA-ALANINE
- CAS Number:299169-95-2
- Molecular formula:C9H10INO2
- Molecular Weight:291.09
141-82-2
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696-41-3
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299169-95-2
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$51.00/50mg
Yield:299169-95-2 54%
Reaction Conditions:
with ammonium acetate in ethanol;Heating / reflux;
Steps:
(+-)-3-Amino-3-(3-iodo-phenyl)-propionic acid (20)
Malonic acid (2.2 g, 21.5 mmol) and 3-iodobenzaldehyde (5 g, 21.5 mmol) were suspended in ethanol (50 mL) and ammonium acetate (1.66 g, 21.5 mmol) was added and the reaction heated to a reflux overnight. The reaction was cooled to room temperature filtered and washed with ethanol followed by ether and dried to afford the product (3.4 g, 11.6 mmol, 54%) as a white solid. 1H NMR (400 MHz, DMSO-d6) δ 7.80 (s, 1H), 7.64 (dd, J=7.8 Hz, 1H), 7.42 (dd, J=7.6 Hz, 1H), 7.16 (dd, J=7.8 Hz, 1H), 7.14 (dd, J=7.6 Hz, 1H), 4.21 (m, 1H), 2.36 (m, 2H).
References:
US2008/193381,2008,A1 Location in patent:Page/Page column 11-12