3-(3-ISOPROPYLPHENYL)-1,1-DIMETHYLUREA synthesis

Yield:55304-10-4 99%

Reaction Conditions:

with pyridine;dmap in dichloromethane at 20;Sealed tube;

Steps:

General procedure A

General procedure: Anilines (1 mmol), N,N-dimethylcarbamoyl chloride (2 mmol), DMAP (1 mmol), and pyridine (4mmol) were sequentially added under air to a reaction tube equipped with a stir bar and aseptum. CH2Cl2 (2 mL) was added by syringe and the resulting mixture vigorously stirred for36-48 h at ambient temperature. After this time, the contents of the flask were extracted withEtOAc. The solution obtained was filtered through the plug of silica gel and anhydrous MgSO4,and then concentrated by rotary evaporation. The residue was purified by flash chromatography,eluting with hexane/EtOAc to afford the product.

References:

Nishikata, Takashi;Abela, Alexander R.;Huang, Shenlin;Lipshutz, Bruce H. [Beilstein Journal of Organic Chemistry,2016,vol. 12,p. 1040 - 1064] Location in patent:supporting information