3-(3-METHOXYPHENYL)-1,1,1-TRIFLUORO-2-PROPANONE synthesis

Yield:22102-09-6 206 mg

Reaction Conditions:

Stage #1: 1-[2-bromo-3,3,3-trifluoro-1-propenyl]-3-methoxybenzenewith potassium tert-butylate in N,N-dimethyl-formamide at 0 - 20;
Stage #2: with hydrogen bromide;acetic acid in water at 20; for 48 h;

References:

Muzalevskiy, Vasiliy M.;Nenajdenko, Valentine G.;Shastin, Aleksey V.;Balenkova, Elizabeth S.;Haufe, Günter [Journal of Fluorine Chemistry,2008,vol. 129,# 10,p. 1052 - 1055] Location in patent:experimental part