3-(3-N-Boc-aMinopropoxy)aniline synthesis

3synthesis methods

Product Name:3-(3-N-Boc-aMinopropoxy)aniline
CAS Number:1175649-60-1
Molecular formula:C14H22N2O3
Molecular Weight:266.34

Carbamic acid, N-[3-(3-nitrophenoxy)propyl]-, 1,1-dimethylethyl ester

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1175649-60-1
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Yield:1175649-60-1 88%

Reaction Conditions:

with hydrogen;palladium 10% on activated carbon in ethanol at 20; for 16 h;

Steps:

62.3

To a solution of 4 (1.20 g, 4.05 mmol) in ethanol (25 mL)) was added Pd/C (0.12 g, 10% w/w) and the reaction mixture was allowed to stir under H₂ atmosphere (1.5 Kg hydrogen pressure) at rt for 16 h. The reaction mixture was filtered through a pad of Celite and concentrated under reduced pressure to get 5 (0.95 g, 88%) as a brownish viscous oil. It was used in the next step without further purification.

References:

WO2009/158571,2009,A1 Location in patent:Page/Page column 238; 239

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References

Methanesulfonic acid 3-tert-butoxycarbonylaMino-propyl ester

112663-43-1
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References