3,4,5-Trichlorobenzaldehyde synthesis
- Product Name:3,4,5-Trichlorobenzaldehyde
- CAS Number:56961-76-3
- Molecular formula:C7H3Cl3O
- Molecular Weight:209.46
104-88-1
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Yield:56961-76-3 80.8%
Reaction Conditions:
with ferric(III) chloride;chlorine;triphenylphosphine in 1,2-dichloro-ethane at 0 - 65; for 3.5 h;Solvent;Temperature;Reagent/catalyst;
Steps:
1-8 Example 2:
A preparation method of 3,4,5-trichlorobenzaldehyde of the present invention, comprising the following steps: adding 183.94g (97%, 1.1mol) anhydrous ferric chloride and 851.94g 1,2 to a 2000mL four-necked flask -Dichloroethane, after mixing evenly, add 141.99g (99%, 1mol) p-chlorobenzaldehyde and 13.25g (99%, 0.05mol) triphenylphosphine, heat up to 65°C, feed 170.16g (2.4g) within 3h mol) chlorine gas, the reaction solution was cooled to 0 °C after the reaction was incubated for 0.5 h, 1 mol/L dilute hydrochloric acid was added dropwise to quench the reaction, and the layers were separated. (80wt% methanol-20wt% water) was recrystallized and dried to obtain 172.34g of white solid, namely 3,4,5-trichlorobenzaldehyde, with a content of 98.2% and a yield of 80.8%.
References:
CN114163321,2022,A Location in patent:Paragraph 0023-0038
120530-42-9
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