![](/CAS/GIF/66684-58-0.gif)
3,4,5-Trifluoronitrobenzene synthesis
- Product Name:3,4,5-Trifluoronitrobenzene
- CAS Number:66684-58-0
- Molecular formula:C6H2F3NO2
- Molecular Weight:177.08
![2,3,4-Trifluoro-6-nitroaniline](/CAS/GIF/148416-38-0.gif)
148416-38-0
115 suppliers
$7.00/250mg
![3,4,5-Trifluoronitrobenzene](/CAS/GIF/66684-58-0.gif)
66684-58-0
205 suppliers
$10.00/1g
Yield:66684-58-0 60%
Reaction Conditions:
Stage #1:6-nitro-2,3,4-trifluoroaniline with tert.-butylnitrite in DMF (N,N-dimethyl-formamide) at 45 - 75; for 2.25 - 4 h;
Stage #2: with hydrogenchloride in DMF (N,N-dimethyl-formamide);water
Steps:
1.4; 2.3 Step 4: Preparation of 3, 4, 5-trifluoronitrobenzene
A solution of t-butyl nitrite (340 mL) in DMF (150 mL) was added to a stirring solution of 6-nitro 2,3, 4-TRIFLUOROANILINE (500 g), obtained in step 3, in DMF (1 L) at 45-75 °C under argon over 3 h. After stirring for 1 h at the same temperature, the reaction mixture was treated with 20% aq. HC1 (2 L) under cooling. The resultant solution was steam distilled to yield 3,4, 5-trifluoronitrobenzene as a yellow liquid and was separated from the distillate (289 g, 62%). The sample obtained this way was found to be ca. 90% pure by GC. 'H NMR : 6 8.13-7. 92 (m, 2H).
References:
DR. REDDY'S LABORATORIES LTD. WO2004/37765, 2004, A1 Location in patent:Page 7; 8-9
![3,4,5-Trifluoroaniline](/CAS/GIF/163733-96-8.gif)
163733-96-8
218 suppliers
$6.00/1g
![3,4,5-Trifluoronitrobenzene](/CAS/GIF/66684-58-0.gif)
66684-58-0
205 suppliers
$10.00/1g
![2,3,4,5-Tetrafluoronitrobenzene](/CAS/GIF/5580-79-0.gif)
5580-79-0
195 suppliers
$10.00/1g
![1,2,5-trifluoro-3-nitrobenzene](/CAS/GIF/66684-57-9.gif)
66684-57-9
86 suppliers
$60.00/100mg
![3,4,5-Trifluoronitrobenzene](/CAS/GIF/66684-58-0.gif)
66684-58-0
205 suppliers
$10.00/1g
![PENTAFLUORONITROBENZENE](/CAS/GIF/880-78-4.gif)
880-78-4
121 suppliers
$30.00/1 g
![1,2,5-trifluoro-3-nitrobenzene](/CAS/GIF/66684-57-9.gif)
66684-57-9
86 suppliers
$60.00/100mg
![3,4,5-Trifluoronitrobenzene](/CAS/GIF/66684-58-0.gif)
66684-58-0
205 suppliers
$10.00/1g