3-(4-Benzyl-piperazin-1-yl)-benzonitrile synthesis
1synthesis methods
- Product Name:3-(4-Benzyl-piperazin-1-yl)-benzonitrile
- CAS Number:247118-08-7
- Molecular formula:C18H19N3
- Molecular Weight:277.36
Yield:247118-08-7 87%
Reaction Conditions:
with potassium carbonate in dimethyl sulfoxide;
Steps:
2 3-(4-benzyl-piperazin-1-yl)-benzonitrile (49b)
To a mixture of 3-fluoro- benzonitrile 43b (1.0 g, 8. 25 MMOL) and K2CO3 (2.27 mg, 16.51 MMOL) in dimethyl sulfoxide (7 mL) was added 1-benzyl piperazine (2. 14 mL, 12. 38 MMOL) and the reaction continued as described above to afford amine 199 g of 49b in 87% YIELDS. 1H-NMR (500 MHz, CDCI3) : 2. 65 (4Hs, t, J = 5.12 Hz), 3.27 (4Hs, t, J = 5.12 Hz), 3.61 (2Hs, s), 7.11-7. 15 (3Hs, m), 7.31-7. 41 (6Hs, m); ESI- MASS: 300.5 (M+23).
References:
WO2005/7625,2005,A2 Location in patent:Page 64