3-(4-BROMO-PHENYL)-5-METHYL-4-PHENYL-ISOXAZOLE synthesis

4synthesis methods

Product Name:3-(4-BROMO-PHENYL)-5-METHYL-4-PHENYL-ISOXAZOLE
CAS Number:181697-19-8
Molecular formula:C16H12BrNO
Molecular Weight:314.18

2466-76-4
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Ethanone, 1-(4-bromophenyl)-2-phenyl-, oxime

181697-18-7
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3-(4-BROMO-PHENYL)-5-METHYL-4-PHENYL-ISOXAZOLE

181697-19-8
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Yield:181697-19-8 60%

Reaction Conditions:

Stage #1: 1-(4-bromophenyl)-2-phenyl-ethan-1-one oximewith lithium diisopropyl amide in tetrahydrofuran;n-heptane;ethylbenzene at -78 - -50;
Stage #2: N-Acetylimidazole in tetrahydrofuran;n-heptane;ethylbenzene at -30 - 0;
Stage #3: with toluene-4-sulfonic acid in methanol; for 16 h;Heating / reflux;

References:

EP1223167,2002,A2 Location in patent:Page 54

2001-29-8 Synthesis

2001-29-8
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181697-19-8
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References

100-39-0
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181697-19-8
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1122-91-4
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