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ChemicalBook CAS DataBase List 3-(4-BROMOPHENYL)-1,4-DIAZASPIRO[4.4]NONAN-2-ONE

3-(4-BROMOPHENYL)-1,4-DIAZASPIRO[4.4]NONAN-2-ONE synthesis

4synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: ammonium acetate; ammonia / ethanol; water / 4 h / 20 °C / Large scale reaction
2: sodium ethanolate / butan-1-ol / 12 h / 80 °C / Large scale reaction

References:

Graham, Jonathan P.;Langlade, Nathalie;Northall, John M.;Roberts, Alastair J.;Whitehead, Andrew J. [Organic process research and development,2011,vol. 15,# 1,p. 44 - 48]