3-(4-Chloro-phenyl)-isoxazole-4-carboxylic acid synthesis

6synthesis methods

Product Name:3-(4-Chloro-phenyl)-isoxazole-4-carboxylic acid
CAS Number:1048922-51-5
Molecular formula:C10H6ClNO3
Molecular Weight:223.61

3-(4-Chlorophenyl)-isoxazole-4-carboxylic acid ethyl ester

29363-98-2
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3-(4-Chloro-phenyl)-isoxazole-4-carboxylic acid

1048922-51-5
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Yield:1048922-51-5 96%

Reaction Conditions:

with hydrogenchloride;acetic acid in water; for 6 h;Reflux;

References:

Porta, Federica;Gelain, Arianna;Barlocco, Daniela;Ferri, Nicola;Marchianò, Silvia;Cappello, Valentina;Basile, Livia;Guccione, Salvatore;Meneghetti, Fiorella;Villa, Stefania [Chemical Biology and Drug Design,2017,vol. 90,# 5,p. 820 - 839]