3-(4-chlorophenoxy)propan-1-amine synthesis
- Product Name:3-(4-chlorophenoxy)propan-1-amine
- CAS Number:50911-60-9
- Molecular formula:C9H12ClNO
- Molecular Weight:185.65
![1H-Isoindole-1,3(2H)-dione, 2-[3-(4-chlorophenoxy)propyl]-](/CAS/20210305/GIF/681428-15-9.gif)
681428-15-9
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50911-60-9
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Yield:-
Reaction Conditions:
with hydrazine hydrate in ethanol at 60; for 16 h;
Steps:
81.2
To a stirred solution of 2-(3-(4-chlorophenoxy)propyl)isoindoline-1 ,3-dione (1 .0 g , 3.17 mmol, 1 .0 equiv.) in ethanol (20 mL) was added hydrazine monohydrate ( 5 mL) and heated the reaction at 60 °C for 16 h. After completion of the reaction , reaction mixture was cooled to room temperature (29 °C) and diluted with diethyl ether and stirred for 10 min. The resulting precipitate was filtered through the sintered funnel and washed with ether. The filtrate was concentrated under reduced pressure to get the crude product; the crude product was carried to next step without any further purification. Weight = 0.58 g crude, as pale yellow liquid. LC-MS: 186.1 [M+H] +.
References:
WO2017/212423,2017,A1 Location in patent:Page/Page column 123
5460-29-7
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106-48-9
485 suppliers
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50911-60-9
32 suppliers
$320.00/5g
106-48-9
485 suppliers
$10.00/5G
50911-60-9
32 suppliers
$320.00/5g