3-(4-CHLOROPHENYL)-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE synthesis

9synthesis methods

Product Name:3-(4-CHLOROPHENYL)-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE
CAS Number:142623-90-3
Molecular formula:C10H6ClF3N2
Molecular Weight:246.62

3-Buten-2-one, 4-(4-chlorophenyl)-1,1,1-trifluoro-, (3E)-

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3-(4-CHLOROPHENYL)-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE

142623-90-3
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$28.60/250MG

Yield:142623-90-3 98%

Reaction Conditions:

with sodium acetate;toluene-4-sulfonic acid hydrazide in ethanol at 80; for 12 h;Schlenk technique;regioselective reaction;

Steps:

General procedure for the preparation of pyrazoles (2)

General procedure: To a 25mL Schlenk were added ketone (0.25mmol), p-toluenesulfonylhydrazide (0.275mmol, 1.1equiv), sodium acetate (0.275mmol, 1.1equiv) and EtOH (2mL). The mixture was stirred at 80°C for 12h and allowed to cool down to room temperature. After removal of the solvent, the residue was purified by column chromatography on silica gel (hexane/EtOAc) or crystallization to afford the pyrazoles 2. The analytical data are in accordance with the literature.^9,16-25

References:

Wang, Yongdong;Han, Jing;Chen, Jie;Cao, Weiguo [Tetrahedron,2015,vol. 71,# 43,p. 8256 - 8262]

1514-82-5 Synthesis