ChemicalBook CAS DataBase List 3-(4-Chlorophenyl)glutaric acid

3-(4-Chlorophenyl)glutaric acid synthesis

8synthesis methods

Product Name:3-(4-Chlorophenyl)glutaric acid
CAS Number:35271-74-0
Molecular formula:C11H11ClO4
Molecular Weight:242.66

141-97-9 Synthesis

141-97-9
781 suppliers
$5.00/25g

104-88-1 Synthesis

104-88-1
614 suppliers
$5.00/25g

35271-74-0
228 suppliers
$22.00/25g

Yield:35271-74-0 95.8%

Reaction Conditions:

with potassium hydroxide in ethanol at 25; for 6 h;Temperature;Solvent;

Steps:

1; 2; 3; 4; 5; 6; 7; 8 (1) Synthesis of crude 3-(4-chlorophenyl)glutaric acid:

Raw material intermediate a 720g, raw material intermediate b 1600g, ethanol 2.8L, potassium hydroxide 100g, 25 degree reaction for 6h were added to the three-necked flask. The system was suction filtered to give crude 3-(4-chlorophenyl) glutaric acid, purity (HPLC) 96.1%.(2) Purification of crude 3-(4-chlorophenyl)glutaric acid:The crude 3-(4-chlorophenyl)glutaric acid (600g) was added to 1.2kg of methyl isobutyl ketone, heated to 60 ° C to dissolve the solid, cooled to 10 ° C for 2 h, suction filtered, 50 ° decompression The purified white crystal product was 575 g, the yield was 95.8%, the purity (HPLC) was 99.9%, and the maximum single impurity was 0.02%.

References:

CN109053425,2018,A Location in patent:Paragraph 0034-0081