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ChemicalBook CAS DataBase List 3-(4-CHLOROPHENYL)ISOXAZOLE

3-(4-CHLOROPHENYL)ISOXAZOLE synthesis

8synthesis methods
-

Yield:31301-39-0 85%

Reaction Conditions:

Stage #1: 4-chlorocinnamaldehydewith p-toluenesulfonylhydroxylamine;potassium carbonate in methanol;water at 20; for 10 h;
Stage #2: with potassium carbonate in methanol;water at 60; for 4 h;regioselective reaction;

References:

Tang, Shibing;He, Jinmei;Sun, Yongquan;He, Liuer;She, Xuegong [Organic Letters,2009,vol. 11,# 17,p. 3982 - 3985] Location in patent:supporting information; experimental part

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