3-[(4-CHLOROPHENYL)SULFANYL]PROPANOIC ACID synthesis

7synthesis methods

Product Name:3-[(4-CHLOROPHENYL)SULFANYL]PROPANOIC ACID
CAS Number:6310-27-6
Molecular formula:C9H9ClO2S
Molecular Weight:216.68

106-54-7
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$10.00/5g

79-10-7 Synthesis

79-10-7
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$20.50/500ml

3-[(4-CHLOROPHENYL)SULFANYL]PROPANOIC ACID

6310-27-6
20 suppliers
$57.50/250mg

Yield:6310-27-6 94%

Reaction Conditions:

with pyridine in tetrahydrofuran at -5 - 5;

Steps:

2 Example 2 Synthesis of 6-chlorothiobenzodihydropyran-4-one

P-chlorothiophenol (117 g, 810 mmol) was added to 200 mL of THF and 1620 mmol of pyridine,At a controlled temperature of -5 ° C to 5 ° C, 69.6 g of acrylic acid (66 mL, 972 mmol) was added dropwise.The reaction mixture was stirred at -5 ° C to -5 ° C for 2 hours.Then it was stirred overnight, adjusted to pH 2 by adding 2N hydrochloric acid, and extracted twice with 300 ml each of ethyl acetate.The organic phase is dried over anhydrous sodium sulfate,The solvent was removed under reduced pressure to obtain 165.7 g of an intermediate,Yield was 94%.

References:

CN110698456,2020,A Location in patent:Paragraph 0007; 0026-0027