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ChemicalBook CAS DataBase List 3,4-Dichloro-5-fluoropyridine

3,4-Dichloro-5-fluoropyridine synthesis

3synthesis methods
514797-99-0 Synthesis
3-Chloro-5-fluoropyridine

514797-99-0
139 suppliers
$6.00/250mg

3,4-Dichloro-5-fluoropyridine

851179-02-7
17 suppliers
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Yield:851179-02-7 78%

Reaction Conditions:

Stage #1: 3-chloro-5-fluoro-pyridinewith n-butyllithium in tetrahydrofuran;hexane;
Stage #2: with 1,1,2-Trichloro-1,2,2-trifluoroethane in tetrahydrofuran;hexane;

References:

Bobbio, Carla;Rausis, Thierry;Schlosser, Manfred [Chemistry - A European Journal,2005,vol. 11,# 6,p. 1903 - 1910]

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