3,4-DIFLUOROPHENYLACETYL CHLORIDE synthesis

Yield:121639-61-0 100%

Reaction Conditions:

with thionyl chloride in 1,2-dichloro-ethane; for 16 h;Heating / reflux;

Steps:

To (3,4-difluoro-phenyl)-acetic acid (2.0 g) dissolved in 1,2-dichloroethane (5 mL) was added thionyl chloride (5 mL) and the mixture was refluxed for 16 hours under argon. The crude mixture was concentrated in vacuo to furnish 2.2 g (100%) of the title compound as a yellow oil. 1H NMR (500 MHz, CDCl3) : 4.10 (s, 2H), 7.00 (m, 1H), 7. 11 (m, 1 H), 7.17 (m, 1H).

References:

WO2005/87754,2005,A1 Location in patent:Page/Page column 50