Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 3,4-DIHYDRO-2H-PYRAN-6-BORONIC ACID PINACOL ESTER
1025707-93-0

3,4-DIHYDRO-2H-PYRAN-6-BORONIC ACID PINACOL ESTER synthesis

3synthesis methods
-

Yield: 50%

Reaction Conditions:

Stage #1:3,4-dihydro-2H-pyran with n-butyllithium;potassium tert-butylate in tetrahydrofuran at -78; for 1 h;Cooling with acetone-dry ice;
Stage #2:Trimethyl borate in tetrahydrofuran at 0; for 1 h;Cooling with ice;
Stage #3:2,3-dimethyl-2,3-butane diol in tetrahydrofuran;acetic acid at 20;

References:

Butkevich, Alexey N.;Corbu, Andrei;Cossy, Janine;Meerpoel, Lieven;Bonnet, Pascal;Stansfield, Ian;Angibaud, Patrick [Organic Letters,2012,vol. 14,# 19,p. 4998 - 5001,4] Location in patent:supporting information