ChemicalBook CAS DataBase List 3,4-DIHYDRO-6-METHYL-2(1H)-QUINOLINONE

3,4-DIHYDRO-6-METHYL-2(1H)-QUINOLINONE synthesis

8synthesis methods

Product Name:3,4-DIHYDRO-6-METHYL-2(1H)-QUINOLINONE
CAS Number:20150-83-8
Molecular formula:C10H11NO
Molecular Weight:161.2

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Yield:20150-83-8 100 %

Reaction Conditions:

with aluminum (III) chloride at 150;

Steps:

Step 2: Synthesis of 6-methyl-3,4-dihydroquinolin-2(1H)-one

Weigh 3-chloro-N-(p-tolyl)propionamide (1g, 5.05mmol) and anhydrous aluminum trichloride (750mg, 5.63mmol) in a 25mL round-bottomed flask, react in an oil bath at 150°C for 5h, and react completely.Add 10% HCl 10mL to the reaction solution, extract with DCM (10mL×3), combine the organic phases, and spin dry under reduced pressure to obtain 835mg of the product as a brown-black solid.The yield is 100%.

References:

CN114436955,2022,A Location in patent:Paragraph 0097; 0101-0102