![](/CAS/GIF/120004-79-7.gif)
3,4-Dihydro-7-(4-chlorobutoxy)-2(1H)-quinolinone synthesis
- Product Name:3,4-Dihydro-7-(4-chlorobutoxy)-2(1H)-quinolinone
- CAS Number:120004-79-7
- Molecular formula:C13H16ClNO2
- Molecular Weight:253.72
![1-Bromo-4-chlorobutane](/CAS/GIF/6940-78-9.gif)
6940-78-9
346 suppliers
$5.00/10g
![3,4-Dihydro-7-hydroxy-2(1H)-quinolinone](/CAS/GIF/22246-18-0.gif)
22246-18-0
617 suppliers
$5.00/5g
![3,4-Dihydro-7-(4-chlorobutoxy)-2(1H)-quinolinone](/CAS/GIF/120004-79-7.gif)
120004-79-7
159 suppliers
$60.00/2 mg
Yield: 95%
Reaction Conditions:
with lithium hydroxide in water;N,N-dimethyl-formamide at 40 - 50; for 3 h;Sealed tube;Large scale;Reagent/catalyst;Solvent;
Steps:
1-2 Example 2 Preparation of 7-(4-chlorobutoxy)-3,4-dihydroquinoline-2(1H)-ketones
Add 1.0kg of 3,4-dihydro-7-hydroxy-2(1H)-quinolinone, 3.15kg of 1-bromo-4-chlorobutane, 3.0L of DMF, 500ml of water, and 270 of lithium hydroxide into a 30L three-necked flask g.After the addition, the temperature was raised to 4050, and the reaction was sealed and kept for 3 hours. After the reaction was completed, water was added to crystallize, filtered with suction, washed twice with water, and the filter cake was dried under reduced pressure to obtain 7-(4-chlorobutoxy)-3, 4-Dihydroquinoline-2(1H)-Ketone dry product 1.48kg, yield 95.0%, purity greater than 98.5%
References:
CN104844585, 2021, B Location in patent:Paragraph 0027-0030
![3,4-Dihydro-7-hydroxy-2(1H)-quinolinone](/CAS/GIF/22246-18-0.gif)
22246-18-0
617 suppliers
$5.00/5g
![1,4-Dichlorobutane](/CAS/GIF/110-56-5.gif)
110-56-5
298 suppliers
$14.00/25mL
![3,4-Dihydro-7-(4-chlorobutoxy)-2(1H)-quinolinone](/CAS/GIF/120004-79-7.gif)
120004-79-7
159 suppliers
$60.00/2 mg
![1-Bromo-4-chlorobutane](/CAS/GIF/6940-78-9.gif)
6940-78-9
346 suppliers
$5.00/10g
![3,4-Dihydro-7-hydroxy-2(1H)-quinolinone](/CAS/GIF/22246-18-0.gif)
22246-18-0
617 suppliers
$5.00/5g
![3,4-Dihydro-7-(4-chlorobutoxy)-2(1H)-quinolinone](/CAS/GIF/120004-79-7.gif)
120004-79-7
159 suppliers
$60.00/2 mg
![3,4-Dihydro-7-(4-bromobutoxy)-2(1H)-quinolinone](/CAS/GIF/129722-34-5.gif)
129722-34-5
351 suppliers
$5.00/250mg