ChemicalBook CAS DataBase List (3,4-DIHYDROXYPHENYL)ACETONITRILE

(3,4-DIHYDROXYPHENYL)ACETONITRILE synthesis

6synthesis methods

Product Name:(3,4-DIHYDROXYPHENYL)ACETONITRILE
CAS Number:1126-62-1
Molecular formula:C8H7NO2
Molecular Weight:149.15

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Yield: 80%

Reaction Conditions:

with pyridine;pyridine hydrochloride;potassium iodide at 150 - 160; for 66 h;Temperature;Concentration;Reagent/catalyst;

Steps:

5 Example 5: (3,4-Dihydroxyphenyl)acetonitrile
A mixture of (3,4-dimethoxyphenyl)acetonitrile (17.8 g, 101 mmol, purchased from Aldrich),pyridine hydrochloride (29.4 g, 254 mmol), potassium iodide (0.83 g, 5.0 mmol), and pyridine(1 ml) was stirred at 150°C for 18 h and then at 160 °C for 48 h. The mixture was dissolved in1 N aqueous HC1 (30 ml) and brine (30 ml), and the mixture was extracted with AcOEt (fourtimes with 60 ml). The combined extracts were dried (MgSO4) and concentrated under reduced pressure; 12.1 g (yield 80%) of(3,4-dihydroxyphenyl)acetonitrile was obtained as a solid, which was used without further purification.

References:

LONZA LTD;SCHMID, Leo;ZOLLINGER, Daniel;ZARAGOZA, Florencio WO2017/149017, 2017, A1 Location in patent:Page/Page column 10