(3,4-DIMETHOXY-BENZOYLAMINO)-ACETIC ACID synthesis
- Product Name:(3,4-DIMETHOXY-BENZOYLAMINO)-ACETIC ACID
- CAS Number:59893-89-9
- Molecular formula:C11H13NO5
- Molecular Weight:239.22
1253936-77-4
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59893-89-9
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Yield:59893-89-9 85%
Reaction Conditions:
with trifluoroacetic acid in dichloromethane at 0 - 20;
Steps:
10
To a solution of the above amide intermediate (3.92 g, 13.14 mmol) in dichloromethane (100 mL) at 0° C is added trifluoroacetic acid (50 mL) and the reaction stirred at room temperature for 72 h with periodic venting. The reaction is concentrated at 40 0C and the resulting oil dissolved in dichloromethane and concentrated again. The oil is slurried in EtOAc (150 mL). The resulting precipitate is filtered, washing with EtOAc to give 2.72 g of the carboxylic acid intermediate in 85% yield
References:
WO2010/126811,2010,A1 Location in patent:Page/Page column 151-152
56-40-6
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3535-37-3
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59893-89-9
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$60.00/500mg
93-07-2
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59893-89-9
19 suppliers
$60.00/500mg