ChemicalBook CAS DataBase List 3,4-Dimethoxyhydrocinnamic acid

3,4-Dimethoxyhydrocinnamic acid synthesis

11synthesis methods

Product Name:3,4-Dimethoxyhydrocinnamic acid
CAS Number:2107-70-2
Molecular formula:C11H14O4
Molecular Weight:210.23

2033-24-1 Synthesis

2033-24-1
631 suppliers
$6.00/25g

120-14-9 Synthesis

120-14-9
756 suppliers
$5.00/25g

2107-70-2
279 suppliers
$6.00/5g

Yield:2107-70-2 2.5 g (47.6%)

Reaction Conditions:

with formic acid;triethylamine in water;benzene

Steps:

19 Preparation of 3-(3,4-dimethoxyphenyl)propionic acid
EXAMPLE 19 Preparation of 3-(3,4-dimethoxyphenyl)propionic acid After weighing in 6.25 ml of the mixture of formic acid and triethylamine (prepared as described in Example 1) to 25 ml of benzene, 4.15 g (0.025 mol) of veratraldehyde and 3.6 g (0.025 mol) of Meldrum's acid were added and the reaction mixture was refluxed for 4 hours. After evaporating the benzene under reduced pressure, 50 ml of water were added to the evaporation residue, the pH value was adjusted to 1 with concentrated hydrochloric acid, then the method of Example 1 was followed. A yield of 2.5 g (47.6%) was achieved, m.p.: 95°-97° C.

References:

Biogal Gyogyszergrar US5350872, 1994, A