3-(4-FLUORO-BENZYL)-PIPERIDINE synthesis

8synthesis methods

Product Name:3-(4-FLUORO-BENZYL)-PIPERIDINE
CAS Number:382637-47-0
Molecular formula:C12H16FN
Molecular Weight:193.26

382637-45-8 Synthesis

382637-45-8
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382637-47-0
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Yield:382637-47-0 99%

Reaction Conditions:

with hydrogenchloride in ethyl acetate at 18; for 17 h;

Steps:

3-(4-fluorobenzyl)piperidine:

tert-Butyl 3-(4-fluorobenzyl)piperidine-l-carboxylate (0.082 g, 0.280 mmol) was added to a HCl/EtOAc solution (0.280 mmol, 8.0 mL). The mixture was stirred at 18 °C for 17 h. The mixture was adjusted to pH 8 with NH₄OH (aq) and the mixture was concentrated in vacuo to afford the title compound (0.054 g, 99%). LCMS (ESI): [M+H] 194.

References:

WO2019/178191,2019,A1 Location in patent:Paragraph 0085; 0089