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3-(4-fluorophenyl)-7-hydroxy-4h-1-benzopyran-4-on synthesis

11synthesis methods
4H-1-Benzopyran-4-one, 3-(4-fluorophenyl)-7-[(tetrahydro-2H-pyran-2-yl)oxy]-

1124174-57-7
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Yield:15584-10-8 85%

Reaction Conditions:

with toluene-4-sulfonic acid in tetrahydrofuran;methanol at 20 - 60;

References:

Matin, Azadeh;Gavande, Navnath;Kim, Moon S.;Yang, Nancy X.;Salam, Noeris K.;Hanrahan, Jane R.;Roubin, Rebecca H.;Hibbs, David E. [Journal of Medicinal Chemistry,2009,vol. 52,# 21,p. 6835 - 6850] Location in patent:experimental part