![](/CAS/GIF/100841-00-7.gif)
3-(4-methoxyphenoxy)propan-1-amine synthesis
- Product Name:3-(4-methoxyphenoxy)propan-1-amine
- CAS Number:100841-00-7
- Molecular formula:C10H15NO2
- Molecular Weight:181.23
![3-(4-methoxyphenoxy)propanenitrile](/CAS/GIF/63815-39-4.gif)
63815-39-4
34 suppliers
inquiry
![3-(4-methoxyphenoxy)propan-1-amine](/CAS/GIF/100841-00-7.gif)
100841-00-7
81 suppliers
$200.00/500mg
Yield:100841-00-7 79%
Reaction Conditions:
with sodium hydroxide in tetrahydrofuran;toluene
Steps:
P.2 Synthesis of 3-(4-methoxyphenoxy)propylamine
PREPARATIVE EXAMPLE 2 Synthesis of 3-(4-methoxyphenoxy)propylamine Under an argon atmosphere, 3-(4-methoxyphenoxy)propionitrile (5.0 g) was dissolved in tetrahydrofuran (20 mL), and borane-tetrahydrofuran complex (1.02 mol/L, 30.0 mL) was added dropwise at 80°C for 10 minutes. After stirring for 3 hours at the same temperature, the reaction liquor was returned to room temperature. In an ice-cold bath, a 4 N aqueous sodium hydroxide solution (30 mL) was added for 10 minutes. After 10 minutes, the mixture was stirred at room temperature for 5 minutes, and then stirred at 80°C for 12 hours. The mixture was returned to room temperature, and toluene (100 mL) was added, and the mixture was stirred for 1 hour, and then insoluble material was removed using Celite. An organic layer was isolated, and washed with water (100 mL x 2 times) and saturated brine (100 mL), and then dried over anhydrous sodium sulfate (80 g). The resultant was filtered, and then the filtrate was concentrated under reduced pressure to obtain a white solid (4.0 g, 79.0%). 1H-NMR (400MHz, CD3OD) δ: 2.05 (quintet, J=7Hz, 2H), 3.07(t, J=7Hz, 2H), 3.71(s, 3H), 4.01(t, J=6Hz, 2H), 6.79-6.85(m,4H).
References:
Kowa Company, Ltd. EP1852426, 2007, A1
![N-[3-(4-methoxy-phenoxy)-propyl]-phthalimide](/CAS/20200331/GIF/100840-46-8.gif)
100840-46-8
3 suppliers
inquiry
![3-(4-methoxyphenoxy)propan-1-amine](/CAS/GIF/100841-00-7.gif)
100841-00-7
81 suppliers
$200.00/500mg
![tert-Butyl 3-bromopropylcarbamate](/CAS/GIF/83948-53-2.gif)
83948-53-2
196 suppliers
$6.00/1g
![4-Methoxyphenol](/CAS/GIF/150-76-5.gif)
150-76-5
761 suppliers
$5.00/5 g
![3-(4-methoxyphenoxy)propan-1-amine](/CAS/GIF/100841-00-7.gif)
100841-00-7
81 suppliers
$200.00/500mg
![4-Methoxyphenol](/CAS/GIF/150-76-5.gif)
150-76-5
761 suppliers
$5.00/5 g
![3-(4-methoxyphenoxy)propan-1-amine](/CAS/GIF/100841-00-7.gif)
100841-00-7
81 suppliers
$200.00/500mg