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3-(4-methoxyphenyl)-1,2,4-thiadiazol-5-amine synthesis

3synthesis methods
5-chloro-3-(4-methoxyphenyl)-1,2,4-thiadiazole

679411-75-7
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3-(4-methoxyphenyl)-1,2,4-thiadiazol-5-amine

138588-25-7
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Yield:138588-25-7 34%

Reaction Conditions:

with ammonia in ethanol at 20;

References:

Jung, Kwan-Young;Kim, Soo-Kyung;Gao, Zhan-Guo;Gross, Ariel S.;Melman, Neli;Jacobson, Kenneth A.;Kim, Yong-Chul [Bioorganic and Medicinal Chemistry,2004,vol. 12,# 3,p. 613 - 623]