3-[(4-METHOXYPHENYL)SULFONYL]PROPANOIC ACID synthesis

6synthesis methods

Product Name:3-[(4-METHOXYPHENYL)SULFONYL]PROPANOIC ACID
CAS Number:91062-23-6
Molecular formula:C10H12O5S
Molecular Weight:244.26

1950-68-1
67 suppliers
$27.00/1g

79-10-7 Synthesis

79-10-7
688 suppliers
$20.50/500ml

3-[(4-METHOXYPHENYL)SULFONYL]PROPANOIC ACID

91062-23-6
14 suppliers
$378.00/1g

Yield:91062-23-6 90%

Reaction Conditions:

in water monomer at 85; for 10 h;

Steps:

6 Example 6:

Take a 25 mL single-necked round bottom flask,Weigh p-methoxybenzenesulfonylhydrazide (1 mmol, 202.2 mg) was added,Acrylic acid (2 mmol, 0.14 mL) was then measured,Add 1mL of water, add the appropriate type of magnet,Device condenser tube reflux. 85oC oil bath heating reaction 10 h.After the reaction, stop heating, natural cooling to room temperature,The pH of the solution was adjusted to 6, EtOAc (100 mL x 3) with 1 mol / L HCl,The organic phases were combined and the organic phase was washed with saturated brine to collect the combined organic phases,Dried over anhydrous sodium sulfate for half an hour,Spin off the solvent to get 3 - p - methoxybenzenesulfonyl propionic acid, white solid 219.8mg, the yield of 90%.

References:

CN106631927,2017,A Location in patent:Paragraph 0019