![](/CAS/GIF/2861-28-1.gif)
3,4-(METHYLENEDIOXY)PHENYLACETIC ACID synthesis
- Product Name:3,4-(METHYLENEDIOXY)PHENYLACETIC ACID
- CAS Number:2861-28-1
- Molecular formula:C9H8O4
- Molecular Weight:180.16
![1,3-Benzodioxole-5-acetic acid methyl ester](/CAS/GIF/326-59-0.gif)
326-59-0
53 suppliers
$75.00/250 mg
![3,4-(METHYLENEDIOXY)PHENYLACETIC ACID](/CAS/GIF/2861-28-1.gif)
2861-28-1
215 suppliers
$14.00/1g
Yield:2861-28-1 99%
Reaction Conditions:
Stage #1:benzo[1,3]dioxol-5-yl-acetic acid methyl ester with potassium hydroxide;water in methanol for 3 h;Heating / reflux;
Stage #2: with hydrogenchloride in water; pH=1
Steps:
1.2; 2.2
A mixture of benzo[ 1,3] dioxol-5-yl-acetic acid methyl ester (1 g, 5.15 mmol) in methanol (2 mL) and 20% aqueous potassium hydroxide (10 mL) were heated at reflux for about 3 hours. Methanol was removed by evaporation, and the aqueous solution was acidified to pH=l with 5% aqueous hydrochloric acid. Standard extractive workup was performed to yield the title product. (910 mg, 99%). 1H NMR (300 MHz, CDCl3) δ 6.78-6.70 (m, 3H), 5.94 (s, 2H), 3.57 (s, 2H); LC-MS: m/z=l 79(M-I)".
References:
AUSPEX PHARMACEUTICALS, INC. WO2008/144602, 2008, A1 Location in patent:Page/Page column 64; 66
![α-Oxo-1,3-benzodioxole-5-acetic Acid](/CAS/GIF/62396-98-9.gif)
62396-98-9
22 suppliers
$110.00/0.25g
![3,4-(METHYLENEDIOXY)PHENYLACETIC ACID](/CAS/GIF/2861-28-1.gif)
2861-28-1
215 suppliers
$14.00/1g
![1,3-BENZODIOXOLE-5-GLYCOLIC ACID](/CAS/GIF/27738-46-1.gif)
27738-46-1
74 suppliers
$50.00/50mg
![3,4-(METHYLENEDIOXY)PHENYLACETIC ACID](/CAS/GIF/2861-28-1.gif)
2861-28-1
215 suppliers
$14.00/1g
![ethyl 2-(1,3-benzodioxol-5-yl)acetate](/CAS/20210111/GIF/26664-86-8.gif)
26664-86-8
9 suppliers
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![3,4-(METHYLENEDIOXY)PHENYLACETIC ACID](/CAS/GIF/2861-28-1.gif)
2861-28-1
215 suppliers
$14.00/1g
![PIPERONYL FORMALDEHYDE](/CAS/GIF/6543-34-6.gif)
6543-34-6
11 suppliers
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![3,4-(METHYLENEDIOXY)PHENYLACETIC ACID](/CAS/GIF/2861-28-1.gif)
2861-28-1
215 suppliers
$14.00/1g