![](/CAS/20180601/GIF/893642-04-1.gif)
3-(4-(trifluoromethoxy)phenyl)prop-2-yn-1-ol synthesis
- Product Name:3-(4-(trifluoromethoxy)phenyl)prop-2-yn-1-ol
- CAS Number:893642-04-1
- Molecular formula:C10H7F3O2
- Molecular Weight:216.16
![Formaldehyde](/CAS/GIF/50-00-0.gif)
50-00-0
846 suppliers
$10.00/25g
![4-(TRIFLUOROMETHOXY)PHENYLACETYLENE](/CAS/GIF/160542-02-9.gif)
160542-02-9
74 suppliers
$29.00/250mg
![3-(4-(trifluoromethoxy)phenyl)prop-2-yn-1-ol](/CAS/20180601/GIF/893642-04-1.gif)
893642-04-1
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Yield:893642-04-1 99%
Reaction Conditions:
Stage #1: 1-ethynyl-4-(trifluoromethoxy)benzenewith ethylmagnesium bromide in tetrahydrofuran at 20; for 0.5 h;Inert atmosphere;
Stage #2: formaldehyd in tetrahydrofuran at 20;Inert atmosphere;
References:
Wang, Chao;Abegg, Daniel;Hoch, Dominic G.;Adibekian, Alexander [Angewandte Chemie - International Edition,2016,vol. 55,# 8,p. 2911 - 2915][Angew. Chem.,2016,vol. 128,# 8,p. 2964 - 2968,5] Location in patent:supporting information