3,5,7-trichloropyrazolo[1,5-a]pyriMidine synthesis
- Product Name:3,5,7-trichloropyrazolo[1,5-a]pyriMidine
- CAS Number:58347-52-7
- Molecular formula:C6H2Cl3N3
- Molecular Weight:222.46
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Yield:58347-52-7 90%
Reaction Conditions:
with N-chloro-succinimide in chloroform at 90; for 2.5 h;Microwave irradiation;
Steps:
7.2 3,5,7-trichloropyrazolo[1,5-a]pyrimidine
To a solution of 5,7-dichloropyrazolo[1,5-a]pyrimidine (2.0 g, 10.64 mmol) in CHC13 (l5mL) was added NCS (1.7Obg, 12.76 mmol). The mixture was heated to 90°C under microwave irradiation for 2.5 hr. The solvent was removed in vacuo and the crude product was purified by flash column chromatography using a 9:1 v/v Hexanes:Ethyl acetate to afford the title compound (2.0 g, 90% yield) as a white crystalline solid. MS m/z 223.76 [M+1].
References:
WO2016/130920,2016,A2 Location in patent:Page/Page column 124; 125
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