3-(5-Chloro-2-fluoro-phenyl)-propionic acid synthesis
- Product Name:3-(5-Chloro-2-fluoro-phenyl)-propionic acid
- CAS Number:135832-52-9
- Molecular formula:C9H8ClFO2
- Molecular Weight:202.61
452-66-4
172 suppliers
$6.00/5g
135832-52-9
23 suppliers
$23.00/250mg
Yield:-
Steps:
Multi-step reaction with 4 steps
1: 13.92 g / N-bromosuccinimide, benzoyl peroxide / CCl4 / 5 h / Heating
2: 1.) NaH / 1.) DMF, 60 deg C, 2 h, 2.) DMF, 60 deg C, 3.5 h
3: 6 N aq. HCl / Heating
4: 10percent aq. NaOH / 8 h / Heating
References:
Shepard;Graham;Hudcosky;Michelson;Scholz;Schwam;Smith;Sondey;Strohmaier;Smith;Sugrue [Journal of Medicinal Chemistry,1991,vol. 34,# 10,p. 3098 - 3105]
71916-91-1
135 suppliers
$22.00/5g
135832-52-9
23 suppliers
$23.00/250mg
2033-24-1
638 suppliers
$6.00/25g
94569-84-3
304 suppliers
$16.00/5g
135832-52-9
23 suppliers
$23.00/250mg