ChemicalBook CAS DataBase List 3',5'-DIACETYL-5-IODO-2'-DEOXYURIDINE

3',5'-DIACETYL-5-IODO-2'-DEOXYURIDINE synthesis

5synthesis methods

Product Name:3',5'-DIACETYL-5-IODO-2'-DEOXYURIDINE
CAS Number:1956-30-5
Molecular formula:C13H15IN2O7
Molecular Weight:438.17

54-42-2 Synthesis

54-42-2
450 suppliers
$6.00/250mg

1956-30-5
36 suppliers
$130.00/100mg

Yield:-

Reaction Conditions:

with HClO₄;acetic anhydride in acetic acid;

Steps:

2 3',5'-Di-O-Acetyl-5-iodo-2'-deoxyuridine (2.2)

3',5'-Di-O-Acetyl-5-iodo-2'-deoxyuridine (2.2) To 5-iodo-2'-deoxyuridine (2.1) (70.8 g, 200 mmol, 1 eq) in an 500 mL Erlenmeyer flask was added acetic acid (72 g, 68.7 mL, 1200 mmol, 6 eq) and acetic anhydride (51 g, 47.1 mL, 500 mmol, 2.5 eq). In a test tube at 0° C., the catalyst for the reaction was prepared by adding HClO₄ (0.5 mL) over acetic anhydride (2 mL). Five drops of the catalyst were added into the Erlenmeyer flask at 0° C. with stirring. The reaction mixture was brought to room temperature and stirred for 4 hours where upon a thick white precipitate formed.

References:

US6444682,2002,B1

13030-62-1 Synthesis