ChemicalBook CAS DataBase List 3,5-Diaminosalicylic acid

3,5-Diaminosalicylic acid synthesis

5synthesis methods

Product Name:3,5-Diaminosalicylic acid
CAS Number:112725-89-0
Molecular formula:C7H8N2O3
Molecular Weight:168.15

831-51-6
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112725-89-0
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Yield:112725-89-0 80%

Reaction Conditions:

with sodium tetrahydroborate;C₅₄H₅₀Cl₂N₂O₃Ru₂ in ethanol at 20; for 3 h;

Steps:

4.3.1. Binuclear ruthenium catalysts
General procedure: A half-sandwich binuclear ruthenium complex (1 mol%) wasdissolved in EtOH (2.0 mL); then appropriate nitroarenes(0.3 mmol) and NaBH4 (1.2 mmol) were added. The resultingmixture was stirred at room temperature in a closed vessel. Aftercompletion of the reaction (monitored by TLC), the crude reactionmixture was extracted with ether (3 x 2 mL). After the solventswere removed in vacuo from the combined organic extracts, thecrude products were loaded directly onto a column of silica gel andpurified by column chromatography using petroleum ether andethyl acetate (1:3) to get the corresponding products.

References:

Nandhini, Raja;Krishnamoorthy, Bellie Sundaram;Venkatachalam, Galmari [Journal of Organometallic Chemistry,2019,vol. 903,art. no. 120984]

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